Self-collected cervicovaginal sampling
Self-collected cervicovaginal sampling for site-of-care primary HPV-based cervical cancer screening: a pilot study in a rural underserved Greek population
03 Νοε 20
11:21 ΠΜ
J Obstet Gynaecol. 2017 Nov;37(8):1059-1064.doi: 10.1080/01443615.2017.1323197. Epub 2017 Jun 20. View Full Text.
Kimon Chatzistamatiou, Εkaterini Chatzaki , Τheocharis Constantinidis , Evangelia Nena, Athena Tsertanidou, Theodoros Agorastos


In the present pilot study, the feasibility of a site-of-care cervicovaginal self-sampling methodology for HPV-based screening was tested in 346 women residing in underserved rural areas of Northern Greece. These women provided self-collected cervicovaginal sample along with a study questionnaire. Following molecular testing, using the cobas® HPV Test, Roche®, HPV positive women, were referred to colposcopy and upon abnormal findings, to biopsy and treatment. Participation rate was 100%. Regular pap-test examination was reported for 17.1%. Among hrHPV testing, 11.9% were positive and colposcopy/biopsy revealed 2 CIN3 cases. Non-compliance was the most prevalent reason for no previous attendance. Most women reported non-difficulty and non-discomfort in self-sampling (77.6% and 82.4%, respectively). They would choose self-sampling over clinician-sampling (86.2%), and should self-sampling being available, they would test themselves more regularly (92.3%). In conclusion, self-sampling is feasible and well-accepted for HPV-based screening, and could increase population coverage in underserved areas, helping towards successful prevention.

Keywords: HPV DNA testing; Self-sampling; cervical cancer screening; human papillomavirus; low resource setting.


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